Josh, 20, and Andrew, 23, have launched Andosh Accessible Gaming, a company that modifies gaming controllers.
The Cameron brothers suffer from Hypermobile Ehlers Danlos Syndrome, a genetic disorder in which there is very little connective tissue between joints.
Among the host of issues the disorder creates is frequent dislocation of joints, from wrists to shoulders to fingers.
"Literally every joint in our body is capable of dislocating," says Josh.
Growing up the two loved video games, but continual injures made it difficult to play.
In 2013 Andrew modified a GameCube controller.
"A couple of years ago a friend said that we could do a lot of good and probably make some money doing this," Andrew said.
"We didn't really know how much demand there would be, but we knew that nobody out there was providing it."
There are companies that will custom make controllers, but that can get expensive.
"We want to be able to modify to meet the needs of the individual while still being affordable," Andrew said.
"We sit down with people and talk to them about what they're looking for and what it is they want to be able to do."
Andosh Accessible gaming, which has been teaming up with the Guelph-Wellington Business Enterprise Centre, will soon have its own web site. The business also repairs game consoles and does custom 3D modelling and printing.
The brothers are also severely allergic to a variety of things, most notably latex, which is the prime reason they had to be almost entirely home schooled.
Their mother Jennifer said that someone playing with a rubber band could release enough latex into the air to cause one of her sons to go into anaphylactic shock.
Setting up a business in the family's west end home, their mother said, "allows them to do something they enjoy and do it in a safe environment."
To contact Andosh Accessible gaming email [email protected].